Roof Plate Embryology

Wang et al 2005.

Roof plate embryology.

The notochord expresses shh. Roof plate is defined as the lmx1a gdf7 region in both anterior and posterior r1. The floor plate responds to shh by producing its own shh and forming a gradient. Failure of the secondary palate to develop correctly may result in a cleft palate disorder.

In cattle prevention of the loss of the polar trophoblast layer leads to ectopic domains of brachyury a gastrulation marker. Rose et al 2009. Roof plate cells provide a secondary source of tgfbeta related signals that are required for the generation of distinct classes of dorsal interneurons. These inductive interactions involve both qualitative and quantitative differences in signaling by tgfbeta related factors and temporal changes in the response of neural progenitor cells.

The formation and development of the secondary palate occurs through signalling molecules shh bmp 2 fgf 8 among others. The floor plate is a structure integral to the developing nervous system of vertebrate organisms. The cerebellar rhombic lip which forms adjacent to the fourth ventricle roof plate in rhombomere 1 is one of two primary progenitor zones in the developing cerebellum. Fate mapping studies have demonstrated that the cerebellar rhombic lip gives rise to cells that populate extra cerebellar regions of the hindbrain including the pontine nuclei machold and fishell 2005.

It has been shown that the floor plate is conserved among vertebrates such as zebrafish and mice with homologous structures in invertebrates such as the fruit fly drosophila and the nematode c. The roof plate of the neural tube responds to those signals by expressing more bmp4 and other transforming growth factor beta tgf β signals to form a dorsal ventral gradient among the neural tube. Our data argue that by e12 5 the early cerebellar anlage has already been subdivided into discrete gene expression domains each of which gives rise to distinct cerebellar populations.